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WormGUIDES is a consortium of biologists, computer scientists, and microscopists seeking to create a novel systems-level resource that will facilitate examination of cellular decisions in the developing nervous system of the nematode C. elegans .
C. elegans stands out as the only organism in which the challenge of understanding cellular origins of an entire nervous system could, in practice, be addressed from all angles—cell birth, migration and differentiation; neurite formation, targeted outgrowth and bundling; synapse formation and tuning of functional circuits—with subcellular resolution for all cells from conception until hatching.