Description: VirtualGlycome.org
virtual (2900) virtualglycome (1) glycome (1)
Ablation of human ST3Gal-4 using CRISPR-Cas9 prevents sialyl Lewis-X biosynthesis on human leukocyte O- and N-linked glycans. It also prevents cell adhesion to all types of adhesion molecules belonging to the selectin family. [Read more]
Mouse, but not human, neutrophil adhesion to IL-1β stimulated vascular endothelial cell is abrogated upon pronase treatment of the leukocytes. Thus, glycolipids may uniquely contribute to human myeloid cell adhesion during inflammation. [Read more]
The low homing and engraftment of stem cells to damaged tissue continues to be a problem for regenerative medicine approaches aimed at resolving cardiology problems. Glycoengineering stem cells with selectin-ligands provides an avenue to address this challenge. [Read more]