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News: Our article revealing the synergistic action of Rarb and Rarg agonists for driving neuronal cell specialization is out! PRODUCT Our laboratory study cell fate decisions from a systems biology perspective, i.e. by aiming to understand their transitions from the reorganization of complex regulatory wires defining their biological state. Marco A. Mendoza and his team; Genoscope 2023 From big-data functional genomics to the reconstruction of  regulatory programs at the basis of biological systems With the

Over years, our team addressed these questions by the development of a universal quality control strategy for ChIP-seq and related datasets ( Mendoza-Parra et al; NAR 2013 ), which has been applied to certify > 80 000 public datasets  and more recently by the release of a user-friendly online resource for ultrafast retrieval, visualization, and comparative analysis of tens of thousands of genomics datasets to gain new functional insight from global or focused multidimensional data integration .