Prof. Jaramillo performed at the LAStheatre Phage Conference Warwick Embajadores para la ciencia 1st International BioDesign Research Conference Lab members Alfonso Jaramillo’s CV Data Software Bioreactors Blog Future Members Postdocs Contact De Novo Synthetic Biology Lab By Prof. Alfonso Jaramillo See more The therapeutics of tomorrow will be individualized, specific, and self-regulated. This could be achieved by synthetic organisms, once we know how to engineer them. The simplest and safest is the bacteri
Another aim is to experimentally create artificial intelligence in living cells. For this, we propose a new way to engineer general-purpose gene circuits without a predefined final behaviour. The circuit dynamics will adapt through reinforcement learning to acquire the desired phenotype only once the cell activates it. We have demonstrated this with E. coli, where we have empowered the cells with the ability to learn board games such as tic-tac-toe. This adaptation is inherited to the offspring but it is no
We will pursue those aims by developing general methodologies to design new biological molecules, viruses and cells with completely new functions. These methodologies rely on automated computational and/or experimental procedures. We have developed computational methodologies to design de novo : RNA, proteins and whole-cell transcriptional circuits. We have also developed automated methodologies to design biomolecules based on experimental procedures. They rely on the combination of phage transduction, evo