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The advent of analytical techniques with extremely low limits of detection has led to dramatic progresses in the field of nucleic acids sequencing. In this project, we build upon current state-of-the-art sequencing technologies to develop novel proof-of-principle technologies for high-throughput protein sequencing and single molecule DNA/RNA sequencing. The work proposed herein will provide:
The results of the project will provide a foundation for the use of novel technologies in a wide range of applications, such as next generation protein sequencing, advanced high-throughput DNA sequencing, biomarker discovery, and genetic diagnostics.