Description: The Open Biochemistry Journal is an open-access online journal dedicated to the rapid publication of original research articles, reviews, letters and guest edited single topic issues in all sub-disciplines of biochemistry .
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The Open Biochemistry Journal is an open-access online journal dedicated to the rapid publication of original research articles, reviews/mini-reviews, letters and guest edited single topic issues in all sub-disciplines of biochemistry (including genomics, gene expression, replication, proteomics, structural biology, enzymology, bioenergetics, metabolism, signal transduction, bioinformatics, cell biology, glycoscience, glycobiology, glycochemistry, glycotechnology, pharmacology, enzyme inhibition, inhibitory
On account of the current COVID-19 pandemic, we have explored the importance of azithromycin and zinc in the treatment of the coronavirus disease by studying the interaction between the cation Zn ++ and azithromycin with the tools of the semi-empirical quantum mechanics PM3 method.
By this approach, the niche in which Zn ++ is located was determined. Zn ++ creates a strong clastic binding between an amine and a hydroxyl group located on the amino-hexose side-chain. Such an interaction serves as a shuttle and allows zinc cation to invade endocellular structures.