Nadace Experientia
Description: We work with drug delivery systems (prodrugs). Our passion is design and synthesis of novel drug delivery vehicles (DDV) aimed for targeted drug delivery. Core of our work consist of phosphate based DDVs, their synthesis, self-cleavage/drug release monitoring and optimization. Optimized prodrugs are used for targeted delivery of therapeutics to the desired site of action (tissue, cell, organ). We are also interested in novel antibiotics, phosphorus chemistry and fluorescent probes.
Research Phosphate based drug delivery vehicles: prodrugs & self immolative chemistry We work on a phosphate based prodrugs to improve undesired properties of common drugs such as absorption, distribution, off-target effects and toxicity. The prodrug-concept is based on chemical modification of original drug molecule in a way of attaching a promoiety (chemical group) to mask the active drug, which helps original drugs to overcome pharmacological barriers. Our phosphate-based promoieties are designed to be a
We focuse on a several series of P-based linkers to study their self-immolation for the purpose of finding the best candidates for both rapid (on-sight action) and slow (e.g. retarded tablets) drug release: Initially, we screen various linkers and their effect on cyclization rate. We are using a light-triggered photocaging group as a good starting point to study the self-immolation process, which we monitor in situ by 31 P NMR. We also want to develop a universal set of linkers, designed for a specific carg
Treatment of systemic fungal mycoses is complex, and a limited number of antifungal drugs represents a challenge in treating invasive fungal infections. Moreover, currently used antifungal drugs have many limitations, including serious adverse effects (off-target toxicity), undesired and hardly predictable drug-drug interactions, and poor pharmacological properties. To decrease the toxicity of current antifungals, we aim for targeted antifungal-drug delivery based on modified azoles or amphotericin B (curre
Nadace Experientia