Jean Fan | Personal site
Description: Lab website of Prof. Jean Fan and team work at Johns Hopkins University
bioinformatics (425) computational biology (105) single cell (31) research lab (24) spatial transcriptomics (3) spatially resolved transcriptomics (3) merfish (3) jhu research opportunities (3)
Spatial organization at both the subcellular-level within cells as well as the cellular-level within tissues play important roles in regulating cell identity and function. Recent technological advances have enabled high-throughput spatially resolved transcriptomic profiling at single-molecule and near-single-cell resolution. We develop machine learning and other statistical approaches as open-source computational software to take advantage of this new spatial information in deriving biological insights rega
Advancements in high-throughput sequencing and imaging technologies have uncovered tremendous genetic, epigenetic, transcriptional, and spatial heterogeneity in various cancers but their impact on clinical outcomes is not well understood. We establish close collaborations with clinical collaborators to develop and apply bioinformatics methods that contribute to a more complete understanding of how cellular heterogeneity impacts tumor progression, therapeutic resistance, and ultimately clinical prognosis. We
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Jean Fan | Personal site