epilepsydesireproject.eu - DESIRE

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Description: DESIRE Development and Epilepsy Project : Strategies for Innovative Research to improve diagnosis, prevention and treatment in children to treat Epilepsy.

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DESIRE is an FP7 funded project (Grant Agreement no: 602531), involving 25 partners in 11 countries, with eight third parties, a total of 2166 person months, with more than 250 researchers involved and 19 clinical centres involved in the clinical trial. It is co-ordinated by Prof. Renzo Guerrini , Dipartimento di Neuroscienze, Area del Farmaco e Salute del Bambino (NEUROFARBA) Universita degli Studi di Firenze, Italy.

DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cognitive and behavioral impairments. EDD are the most frequent drug-resistant pediatric epilepsies carrying a lifelo

Although EDD collectively represent a major medical and socio-economic burden, their molecular diagnosis, pathogenic mechanisms (PM) and rationale treatment are poorly understood.

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