Machine learning and genomics
New York Genome Center / Columbia University
The Knowles lab develops and applies machine learning methods for data analysis challenges in genomics. We're particularly interested in understanding the role of transcriptomic dysregulation, especially that involving RNA splicing, across the spectrum from rare to common genetic disease. This involves better characterization of the genetic and environmental factors contributing to mRNA expression and splicing variation. We collaborate with diverse research groups at NYGC and beyond collecting large-scale g