Description: [click for university staff page] Jonathan Clayden and his research group work on the construction of molecules with defined shapes, and are particular interested in exploring and exploiting molecular conformation. The shape of a molecule dictates its function, and understanding conformational effects allows us to make molecules that behave in specific ways. We use the understanding…
[click for university staff page]
Jonathan Clayden and his research group work on the construction of molecules with defined shapes, and are particular interested in exploring and exploiting molecular conformation .
The shape of a molecule dictates its function, and understanding conformational effects allows us to make molecules that behave in specific ways. We use the understanding we gain from conformational studies to design and synthesise molecular communication devices that transmit information to remote reactive sites, and to make conformationally-defined molecules (foldamers) that mimic biological function . We also explore new classes of atropisomers for potential use as chiral ligands .