Description: Bhat Lab is a precision medicine research program dedicated to improving long-term outcomes after Liver Transplantation in Toronto at UHN.
While an increasing number of Canadians have benefited from life-saving liver transplantation with excellent short-term survival, there has been no significant improvement in longer-term outcomes and survival beyond one year. Our precision medicine program uses a combination of laboratory, bioinformatics, and data science (artificial intelligence and biostatistical) tools to examine metabolic and malignant complications (specifically Recurrent Hepatocellular carcinoma, Non-alcoholic Steatohepatitis, and Pos
We employ a bench-to-bedside paradigm that connects clinical outcomes with basic research using tools from systems biology, including bioinformatic analysis of ‘omic datasets (e.g., methylation, whole exome sequencing, transcriptomic, intestinal microbiome), network and integrative analysis. Validation of findings is performed using patient samples/clinical cohorts, as well as in silico, in vitro and in vivo approaches.
Our work will contribute to a better understanding of the key pathways that underpin these clinical conditions, providing insights that inform more personalized preventive and therapeutic strategies post-transplant.