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In an article published in Nature Communications, researchers from Benaroya Research Institute (BRI) and Yale University confirm that COVID-19 immunization does not drive the development of new autoantibodies.
While safe overall, mRNA-based COVID-19 vaccines are associated with rare vaccine-related adverse events. These events coupled with observations that acute SARS-CoV-2 infection is associated with increased autoantibodies brought into question whether COVID-19 vaccination might also promote the development of autoantibodies, particularly in patients with preexisting autoimmune disease.
The results of this work bolster the emerging safety profile of mRNA vaccines and highlights their ability to decouple SARS-CoV-2 immunity from the autoantibody responses observed during acute COVID-19 infection.
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