Description: The main research interest of our lab is to elucidate the molecular and cellular mechanisms underlying sleep disorders and psychomotor retardation.
sleep (889) sleep disorders (92) ahds (5) synaptic plasticity (4) mct8 (2) hypocretin (2) molecular neuroscience (1) lior appelbaum (1) appelbaum lab. (1)
https://youtu.be/dsc0Uqu0k18
Sleep and sleep disorders: Sleep is an evolutionarily conserved process that is vital for animal survival. Sleep disturbances affect a large portion of the general population and represent a major health burden. Although sleep clearly improves brain performance, the function of sleep is unclear. We have characterized sleep, cloned sleep genes, visualized sleep circuits, and established zebrafish models for sleep disorders. We also found that sleep enable efficient nuclear maintenance of single neurons.
Hypocretin/Orexin neurons in zebrafish larva