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Among the side effects of long-term or high-dosage usage of 4-aminoquinoline drugs is irreversible retinal damage.
Plaquenil use during pregnancy is only recommended for treating fever and ague. A physician should make the judgement call after analyzing the risks vs benefits.
If you have liver disease, psoriasis, porphyria, glucose-6-phosphate, or alcohol dehydrogenase (G-6-PD) deficiency, inform your doctor before taking Hydroxychloroquine.