Saez-Rodriguez Group
python (3894) neuroscience (658) neuroimaging (54) machinelearning (44) nilearn (1)
Current version: 1.0.1, Jan 09, 2018
GDSCTools is a free open-source Python library dedicated to the study of drug responses in the context of the GDSC (Genomics of Drug Sensitivity in Cancer) project. The main developer is Thomas Cokelaer (Institut Pasteur) , and it is a joint effort of the groups of Mathew Garnett (Sanger Institute) and Julio Saez-Rodriguez (RWTH Aachen & EMBL-EBI) .
It contains utilities to find significant associations between drugs and genomic features (e.g., gene mutation) based on an ANOVA analysis. Other methods, such as multi-factorial linear models based on Elastic Net are also available. Besides, the library should also be useful for manipulating dedicated data sets such as IC50 (drug response) or MoBEM (genomic features) data structures. Hence, we hope that GDSCTools serves as basis for other scientists to develop further methods.
Saez-Rodriguez Group