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SINGAPORE, 19-May-2023 — /EPR BIOTECH NEWS/ — Multiple myeloma is an incurable neoplasia of plasma cells causing anaemia, hypercalcemia, renal insufficiency, and bone lesions. This is due to malignant plasma cells accumulating in bone marrow — the soft, spongy tissue at the centre of bones — crowding out the normal plasma cells that help fight infection. Multiple myeloma usually presents at an potentially curable, asymptomatic stage (also known as smouldering/indolent). However, around 50% of patients go on
Austrianova and San Raffaele University & Research Hospital, Milan, Italy have just announced the initiation of a Joint Development Programme with the aim of creating a treatment to prevent the progression of multiple myeloma to full blown disease by manipulating the microbiome.
The group of Dr. Matteo Bellone, leader of Cellular immunology Unit at San Raffaele University & Research Hospital, has shown that Prevotella melaninogenica , a commensal bacterium of the human gastrointestinal microbiota, can protect against the progression of relatively benign asymptomatic multiple myeloma to the aggressive form of the disease. Delivery of Prevotella melaninogenica in preclinical animal models prevents this progression (Calcinotto et al., 2018) but large doses of the bacteria are needed s
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